[ABSTRACT FROM AUTHOR]; Spanish: La nefrotoxicidad del cisplatino debe tenerse siempre presente como causa potencial de daño renal en todo fracaso. OBJECTIVE: To review recent advances in the understanding of the mechanisms of cisplatin nephrotoxicity. Factors affecting this toxicity and agents that may. Concluimos que la tiopronina, droga efectiva en la protección contra la nefrotoxicidad por cisplatino, es también efectiva para proteger en contra de la.

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Cisplatin-induced apoptosis in pdeficient renal cells via the intrinsic mitochondrial pathway. Weights of the kidneys were also noted. Role of Tribulus terrestris Linn. Thus, together with other herbal extracts, T. This jefrotoxicidad may be abridged.

Differential roles of hydrogen peroxide and hydroxyl radical in cisplatin-induced cell death in renal proximal tubular epithelial cells.

Renal tubular apoptosis has been suggested as a mechanism of cisplatin-induced acute kidney injury. Cisplatin cis-diamminedichloroplatinum II CPa most effective chemotherapeutic agent, has been successfully used in treatment of a variety of solid tumors, including ovary, testis, bladder, head and neck, lung, cervix, and endometrium Baek et al. The present study amid to investigate the Tribulus terrestris Hydroalcoholic extract effect on cisplatin-induced apoptosis in mice kidney.

Protective effect of hydroalcoholic extract of Tribulus terrestris on Cisplatin induced renal tissue damage in male mice. Hoboken7: Tribulus terrestris L is also reported to have cooling, diuretic, tonic and aphrodisiac effects Sugunavarman et al. Effect of alcoholic extract of Nigella sativa on cisplatin-induced toxicity in rat.

The present study demonstrated T. Zhong Yao Cai, 26 5: The animals were provided with standard diet pellets and water ad libitum. Casilla D Temuco – Chile Tel.: The role of oxygen free radicals in cisplatin-induced acute renal failure in rats. Cisplatin nephrotoxicity should always be considered as a potential cause of renal damage in acute renal failure installed in the context of its use. Different parts of Tribulus terrestris L have been used traditionally in treating a variety of diseases including hypertension and coronary artery diseases, diabetes and hyperlipidemia, as well as fungal diseases Sharma et al.


Slides were mounted using glass cover slips and then analyzed immediately under a fluorescent microscope Olympus, Japan. To avoid this side effect, prescription of complementary synthetic or herbal protective agents has been investigated against CP-induced nephrotoxicity Saleh et al.

The effect of toxic dose of cisplatin 5. Cisplatin; Nephrotoxicity; Tribulus terrestris; Kidneys; Protective effect. Jan-Apr, Issue 1, p Oxidative agents, principally involving reactive oxygen species ROS in renal tubular cells, are considered as the main mechanisms of nephrotoxicity of CP.

Mice were distributed at random into five groups each of six mice and individually put in metabolic cages and treated as follows: Research protocols were approved by the local ethics committee.

Extracting method was described previously Keshtmand et al. No warranty is given about the accuracy of the copy.

Protective effect of an aphrodisiac herb Tribulus nefrotodicidad Linn on cadmium-induced testicular damage. Antihypertensive and vasodilator effects of methanolic and aqueous extracts of Tribulus terrestris in rats.


Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: However, users may print, download, or email articles for individual use. Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice.

Hepatoprotective activity of Tribulus terrestris extract against acetaminophen-induced toxicity in a freshwater fish Oreochromis mossambicus. Electronic Journal of Biomedicine. Copyright of Electronic Journal of Biomedicine is the property of Electronic Journal of Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder’s express written permission.


Then, the tinctured grains were extracted by percolation method and extract concentrated in a vacuum and dried in the flat surface. Tribulus terrestris extract protects against mercury-induced.

The study demonstrates that extract of TT could have protective effect on cisplatin- induced apoptosis of kidney. Experiments were started after one week of adaptation.


Among its mechanisms of renal functional impairment are: Users should refer to the original published version cispltino the material for the full abstract. Tribulus terrestris TT has been used as an synthetic or herbal nerfotoxicidad agents for kidney disorders.

It is an efficient platinum-derived alkylating agent that acts in unspecific phases of the cellular cycle against proliferating and resting cells Lirdi et al. Then, fresh fruits of T. The effect of toxic dose of cisplatin CIS 5. Studies on the protective effect of dietary fish cis;latino on cisplatin induced nephrotoxicity in rats. Uno de los principales efectos secundarios limitantes del cisplatino es la nefrotoxicidad. CP nephrotoxicity pathological feature, the major adverse effect of CP in approximately one third of patients during chemotherapy in clinic, it has been the cause of renal cell damage, cell death and the loss of renal function or acute renal failure, especially in renal tubules Jiang et al.

The obtained extract weight, 6.