Transdermal fentanyl matrix patches Matrifen and Durogesic DTrans are bioequivalent. Kress HG(1), Boss H, Delvin T, Lahu G, Lophaven S. The pharmacokinetic profiles of the two commercially available transdermal fentanyl patches Matrifen® ( μg/h) and Durogesic® DTrans® ( μg/h), used to. Some recent orders of Durogesic DTrans (fentanyl; Janssen-Cilag) 25µg/hour transdermal patches, batch number 8FCSC00, may have been incorrectly filled.

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Adapted from 1 Foley KM.


Renal impairment Even though impairment of renal function is not expected to affect fentanyl elimination to a clinically relevant extent, caution is advised because fentanyl pharmacokinetics has not been evaluated in this patient population see section 5. Fentanyl then becomes available to the dtrns circulation. Following a hour patch application, the mean fentanyl half-life ranges from 20 to 27 hours.

If concomitant use of Durogesic DTrans with a CNS depressant is clinically necessary, prescribe the lowest effective dosages and minimum duration for both drugs, and follow patients closely for signs of respiratory depression and sedation.

Skip to main content Skip to navigation. Durogesic DTrans should not be used during pregnancy unless clearly necessary. As a result of continued absorption of fentanyl from the skin depot after removal of the patch, the half-life of fentanyl after transdermal administration is about 2- to 3-fold longer than intravenous administration. Durogesic DTrans should be applied immediately upon removal from the sealed package.

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transdermal fentanyl (Durogesic D Trans 12mcg/hr)

These actions can be followed by administration of a specific opioid antagonist such as naloxone. Therefore, after a dose increase, patients should wear the higher dose patch through two hour applications before any further increase in dose level is made. Equianalgesic potency conversion In patients currently taking opioid analgesics, the starting dose of Durogesic Durogssic should be based on the daily dose of the prior opioid.

Treatment For management of respiratory depression, immediate countermeasures include removing the Durogesic DTrans patch and physically or verbally stimulating the patient. Hepatic impairment Patients with hepatic impairment should be observed carefully for signs of fentanyl toxicity and the dose of Durogesic DTrans should be reduced durogezic necessary see section 4.


An optimal therapeutic concentration range of fentanyl can therefore not be established. Fentanyl may produce bradycardia and should therefore be administered with caution to patients with bradyarrhythmias.

Patients with renal or hepatic impairment should be observed carefully and the dose should be individualised based upon the status of the patient see sections 4.

Symptoms and signs The manifestations xtrans fentanyl overdose are an extension of its pharmacologic actions, the most serious effect being respiratory depression.

Patients reach and maintain a steady-state serum concentration that is determined by individual variation in skin permeability and body clearance of fentanyl. Subscribe to our dtarns alerts. Even though impairment of renal function dtrasn not expected to affect fentanyl elimination to a clinically relevant extent, caution is advised because fentanyl pharmacokinetics has not been evaluated in this patient population see section 5.

Table 3 etrans for adult patients who are on a stable, and well-tolerated, opioid regimen conversion ratio of oral morphine to transdermal fentanyl approximately equal to Apply the patch to the skin by applying light pressure with the palm of the hand for about 30 seconds.

The Durogesic DTrans patch should be replaced dtrxns 72 hours. Tables 1, 2, and 3 should only be used to convert from other opioids to Durogesic DTrans and not from Durogesic DTrans to other therapies to avoid overestimating the new analgesic dose and potentially causing overdose. Each patch is marked: A new patch should be applied to a different skin site after removal of the previous transdermal patch. This may occur within the recommended dose. If there is hair, do not shave it shaving irritates the skin.

Its primary therapeutic actions are analgesia and sedation. In addition, the drug may be used to prevent or relieve tachypnea and postoperative emergence delirium.

Some parts of the site may not work properly if you choose not to accept cookies. The potential for serious or life-threatening hypoventilation exists regardless of the dose of Duogesic DTrans transdermal system administered. Insomnia, Depression, Anxiety, Confusional state, Hallucination.

Paediatric population The dtranz of Durogesic DTrans was evaluated in 3 open-label studies in paediatric dirogesic with chronic pain, aged 2 to 17 years, inclusive.


If the site of Durogesic DTrans application requires cleansing prior to application of the patch, this should be done with clear water. No risk was identified in the paediatric population beyond that expected with the use of opioids for the relief of pain associated with serious illness and there does not appear to be any paediatric-specific risk associated with Durogesic DTrans use in children as young as 2 years old when used as directed.

transdermal fentanyl (Durogesic D Trans 12mcg/hr)

The tendency of tolerance development varies widely among individuals. Available for Android and iOS devices. Patients and their carers must be instructed that Durogesic DTrans contains an active substance in an amount that can be fatal, especially to durogexic child.

Initial evaluation of the maximum analgesic effect of Durogesic DTrans cannot be made before the patch is worn for 24 hours. Durogesic DTrans should be applied to non-irritated and non-irradiated skin on a flat surface of the torso or upper arms. Optimise drug therapy for your patients. Because fentanyl is metabolised to inactive metabolites in the liver, hepatic impairment might delay its elimination. Extra caution should be used in patients dtrzns chronic constipation.

Make certain that the edges of the patch are adhering properly. However, as the influence of renal impairment on the pharmacokinetics of fentanyl has not been evaluated, caution is advised see sections 4. Your doctor will know which medicines are safe to take with Durogesic DTrans.

Depending on the additional analgesic needs and the pain status of the child, it may be decided to increase the dose. Avoid touching the adhesive side durogesiic the patch. Caution is advised when Durogesic DTrans is co-administered with medicinal products that affect the serotonergic neurotransmitter systems.

Respiratory depression following an overdose may outlast the duration of action of the opioid antagonist. Fold the sachet at dueogesic notch, then carefully tear the sachet material.