Lupus miliaris disseminatus faciei (LMDF) is a granulomatous eruption characterized by monomorphic, reddish-brown papules and nodules predominantly. A biopsy specimen revealed epithelioid cell granulomas with central necrosis, consistent with a diagnosis of lupus miliaris disseminatus faciei (Figure 2). Lupus miliaris disseminatus faciei (LMDF) first described in is an uncommon dermatosis of unknown etiology with characteristic.

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Some of the early lesions have demonstrated lymphocytes within follicular walls [ 29 ].

In conclusion, the nm diode laser should be considered for the treatment of lupus miliaris disseminatus faciei not only because of the chronic nature of the disease but also because of its tendency to result in permanent scarring, especially in cases that are resistant to standard medical care, as in the case reported herein.

Create a free personal account to download free article PDFs, sign up for alerts, customize your interests, and more. Typical skin lesions of LMDF are multiple discrete, smooth, mm, monomorphic, symmetrical reddish-brown or brown-to-yellowish dome-shaped translucent papules and nodules occurring on the chin, forehead, cheeks, and eyelids. Additionally, sarcoidosis can be distinguished by physical examination, chest X-ray, and laboratory tests, and infectious disorders by the absence of microorganisms detected through histochemical stains PAS, Ziehl-Neelsen.

It responds poorly to treatment with oral tetracycline-class antibiotics and oral isotretinoin, which are considered the mainstay of treatment. Support Center Support Center.


Tuberculin test was negative. Dermatol Online J ; This laser has been shown to target pilosebaceous units, perhaps reducing the production of proinflammatory agents that may underlie lupus miliaris disseminatus faciei. Therapy is difficult with variable efficacy and several therapeutic modalities, e.

Treatment with the nm diode laser. However, some authors have proposed that there is a histopathologic spectrum of lesions that can be divided into three stages: See the DermNet NZ bookstore.

Create a personal account to register for email alerts with links to free full-text articles. Fragmented skin biopsy showing mild focal acanthosis with focal follicular plugging. The records of 10 patients mean age, Red papules on the face with secondary scarring. Treatment With the nm Diode Laser.

Lupus miliaris disseminatus faciei pathology

Get free access to newly published articles. Lupus miliaris disseminatus faciei. A final diagnosis of lupus miliaris disseminatus faciei was made based on the above-mentioned features.

Privacy Policy Terms of Use. The presence of granulomas in the vicinity of ruptured follicles in fully developed lesions lends further support to this theory [ 9 ]. By 16 weeks, a moderate improvement had been achieved, despite lpus residual depressed scars, and minocycline was tapered to mg every other day and prednisolone to 5 mg every other day, which she maintained for an additional eight weeks Figure 3.

Histopathologic features reviewed included disseminauts of caseation necrosis, depth of granuloma, presence of lymphocytic infiltrate, disruption of hair follicles, and presence of multinucleated giant cells. This left few, if any, established treatments for her condition, which remained active.


Lupus miliaris disseminatus faciei pathology | DermNet NZ

This article sisseminatus been cited by other articles in PMC. The presence of nuclear dust and neutrophils within the zones of caseation necrosis suggests that neutrophils may indeed play a role in inducing this change [ 9 ].

With such an approach, a wide variety of granulomatous disorders might qualify for inclusion, including granulomatous rosacea, granulomatous perioral dermatitis, acneiform folliculitis, and a number of cutaneous infections. Further information is needed to clarify the diagnosis, etiology, and pathogenesis of this disease, but an unusual host response to folliculitis or follicular injury likely plays a role in most cases. Our website uses cookies to enhance your experience.

Lupus miliaris disseminatus faciei

Overall, clinical response to all treatments has been poor. However, multiple extrafacial sites of involvement and one case without any facial involvement have been reported [ 167 ]. Histologic spectrum of LMDF. Lupus miliaris disseminatus faciei treated with 1,nm nonablative fractionated laser resurfacing: It presents with pale papules which may be confused with sarcoid or syringoma clinically.

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